What hazard increases when heat is not removed effectively during scale-up?

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Prepare for the SAChE Chemical Reactivity Hazards Test with detailed flashcards and multiple choice questions. Each question is equipped with helpful hints and explanations to ensure you're exam ready!

Multiple Choice

What hazard increases when heat is not removed effectively during scale-up?

Explanation:
When heat removal isn’t effective during scale-up, heat can accumulate faster than it can be carried away. In exothermic reactions, temperature rises speed up the reaction rate, which generates even more heat. This creates a positive feedback loop known as thermal runaway. In larger scales, the heat transfer area to volume ratio often decreases, making cooling even harder and increasing the chance of runaway, vessel damage, venting, or release of hazardous materials. So the hazard increases due to heat buildup and the potential for runaway.

When heat removal isn’t effective during scale-up, heat can accumulate faster than it can be carried away. In exothermic reactions, temperature rises speed up the reaction rate, which generates even more heat. This creates a positive feedback loop known as thermal runaway. In larger scales, the heat transfer area to volume ratio often decreases, making cooling even harder and increasing the chance of runaway, vessel damage, venting, or release of hazardous materials. So the hazard increases due to heat buildup and the potential for runaway.

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